| Pair Name | Curcumin, Pyridoxine | ||
| Phytochemical Name | Curcumin (PubChem CID: 969516 ) | ||
| Anticancer drug Name | Pyridoxine (PubChem CID: 1054 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Curcumin, Pyridoxine | |||
| Disease Info | [ICD-11: 2B91.Z] | Colorectal cancer | Investigative | |
| Gene Regulation | Down-regulation | Phosphorylation | PIK3CA | hsa5290 |
| Down-regulation | Phosphorylation | CTNNB1 | hsa1499 | |
| Down-regulation | Phosphorylation | RELA | hsa5970 | |
| In Vivo Model | Male FVB mice (4 weeks old) were used in this study. | |||
| Result | C + B is superior to either agent alone in preventing obesity-promoted colorectal carcinogenesis. Augmented suppression of procancerous signaling pathways may be the means by which this augmentation occurs. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combined Supplementation with Vitamin B-6 and Curcumin is Superior to Either Agent Alone in Suppressing Obesity-Promoted Colorectal Tumorigenesis in Mice. J Nutr. 2021 Dec 3;151(12):3678-3688. doi: 10.1093/jn/nxab320. | Click |
